A pillowtop mattress is a perfect pairing of soft and firm all in one mattress. The pillow layer over the top of the mattress allows the person to have some cushion before resting on the firm mattress below it. Cleaning a pillowtop mattress isn't different than cleaning any other mattress, but the rewards of taking the time to do it are more than plenty just in sanitary reasons alone.
Vacuum off the mattress using the vacuum cleaner attachment. Be sure to lift the lip of the pillow top and get underneath.
Mix a solution of vinegar and water in a spray bottle and lightly mist the mattress with it.
Mix powdered laundry detergent and water into a paste and apply it to stains with a soft clean cloth. Gently scrub the stain with the paste and allow it to sit on the stain for five minutes. Use the vacuum cleaner attachment to pick up any residual dry paste.
Sprinkle baking soda all over the mattress and allow it to sit for three or four hours before vacuuming it up.
Set the mattress outside on a sunny day to soak in the sunlight. It may be helpful to lay a clean blanket out for the mattress to lie on. After at least a couple of hours, flip the mattress over so the other side can get some sunlight too. This will help to kill any mold or mildew spores that may be inside the mattress.