Mice seek entrance into sheds when they're hungry, ready to nest or cold. According to the Internet Center for Wildlife Damage Management, mice can enter openings larger than 1/4 inch, jump as high as 18 inches from a floor onto an elevated surface and can travel considerable distances crawling upside-down along screen wire. Consider mouse-proofing your shed to keep the pests at bay.
Fasten a metal floor threshold onto the surface area directly in front of your shed door and cover all shed windows with protective metal window screens to keep mice out. You can purchase metal floor thresholds and metal window screens at hardware stores.
Seal all small holes, openings or cracks on your shed with steel mesh wire, steel scouring pads or caulking. Mice can get through any hole that will admit the tip of your little finger. Stuff stainless steel scouring pads inside each hole or opening and seal it closed with caulking or attach steel mesh wire over each opening.
Attach metal guards to all drains or pipes leading into or out of your shed. Metal guards can be used to prevent rats from climbing augers, pipes or wires leading to buildings.
Remove all grass, weeds, trash and wood or log piles from around your shed. Mice are attracted to areas covered by dense vegetation, trash or wood. Keep all grass or weeds around your shed cut regularly. Burn all trash and unwanted wood located around your shed. The University of Georgia College of Agricultural and Environmental Sciences recommends storing wood or logs at least 1 foot off the ground, away from buildings.
Spray a store-brand mice repellent, such as predator urine, evenly around your shed. Follow all label directions carefully. Reapply the repellent on a regular basis and after every rainy day to ensure maximum success.