Herbicides containing the chemical 2,4-D kill weeds without killing your lawn, but you have to get the mixture right for an effective and non-harmful treatment. Before mixing, keep in mind that 2,4-D is post-emergent, meaning the chemical has to come into contact with a leaf during the active growing stage, so you can only apply when weeds are growing. In mild, frost-free climates where everything grows all the time, you can apply 2,4-D anytime of year; otherwise, only use it in spring, summer and fall. Use this effective pesticide on lawns, but keep it away from the food garden and off the flowerbeds.
Put on coveralls over your clothes, or wear long pants and a long-sleeve shirt. Put on protective goggles of a face shield and heavy waterproof gloves.
Fill a handheld or backpack style herbicide sprayer half full with clean water.
Mix 2 tablespoons (1 fluid ounce) of 2,4-D weed killer for every 1 gallon volume in your sprayer and then fill the sprayer up the rest of the way with water.
Use 1 gallon of water mixed with 2 tablespoons of 2,4-D weed killer to cover 1,000 square feet of lawn or grass. Mix 4 tablespoons in 2 gallons of water to cover 2,000 square feet and 6 tablespoons in 3 gallons of water for 3,000 square feet of lawn.
Mix 1 tablespoon in 1/2 gallon of water for small spot treatments. Spray the weeds directly until the leaves are saturated.