Natural Rat Poison

Domesticated rats are loving pets, but the wild species will infest homes and public buildings, spreading disease and parasites as they seek food and shelter. According to the Illinois Department of Public Health, cleanliness and good sanitation will limit rats' ability to survive indoors and around homes but may not prevent infestation. Commercial rat poisons can be harmful to the environment and lethal to pets, barn animals and children. However, poison may be necessary if traps or natural deterrents, such as pet cats, predator urine, dog fur, pepper spray, ammonia or peppermint oil-soaked cotton balls, are unsuccessful.

Improperly-stored food and unsanitary conditions can encourage rat infestation.

Vitamin D

A lethal dose of rat poison made from naturally occurring vitamin D will induce hypercalcemia, raising the calcium levels in rats' blood vessels, kidneys, stomach and lungs. Symptoms range from internal bleeding to kidney failure and usually begin 18 to 36 hours after ingestion. Many commercial products mix vitamin D with an anticoagulant poison, making it a less natural option, so be sure to check product labels.

Poisonous Plants

Oleander is toxic to rats.

Many plants are toxic to small animals, including rats. Growing them around your property may help to prevent and control rat infestation, but remember that they will harm cats, dogs and other small animals. Many plants only cause a mild reaction and serve as deterrents rather than poison, but oleander, which causes paralysis, respiratory failure and cardiac arrest, and Dieffenbachia (spotted dumbcane), which leads to throat swelling and suffocation, are both lethal.

Non-Chemical Poisons

Some commercial products contain no chemicals at all and can be considered natural rat poisons. These products contain alpha-cellulose derived from wood and plant fibers, along with wheat and molasses. When rodents eat these products, they experience blood thickening, dehydration and coma leading to death. These natural poisons are safe to use around children, pets and food and are fully biodegradable.

Past Solutions

Many natural rodenticides have been phased out of use (and made illegal in some cases) due to high toxicity levels and danger to humans. One of these is strychnine, a colorless, crystalline alkaloid that causes muscle convulsions and death due to asphyxia or exhaustion. It is still used as gopher bait. Other substances used previously include arsenic, barium, cyanide and yellow phosphorus.

Synthetic Poisons

Anticoagulants are not natural poisons even though their chemical components are derived in part from plants. They cause severe internal bleeding, shock to the circulatory system and death in one to two weeks. These poisons can contaminate the environment, other animals and children. The safer synthetic compound zinc phosphide is mixed with food bait and reacts with rats' digestive acid to form toxic phosphine gas. This poison is considered specific to rodents and rarely causes harm to other local wildlife, although birds, cats and dogs are susceptible.