Things You'll Need
White cloths
Eye dropper
Fingernail polish remover with acetone
Dry cleaning solvent
Sponge
Hydrogen peroxide, optional
Tip
For light-colored mattresses, you can also use a few drops of hydrogen peroxide if the dry-cleaning solvent didn't totally remove the stain.

While it may be comfortable to apply fingernail polish when sitting on a mattress, you're also more likely to spill it as you shift positions. However, you can remove most fingernail polish stains from mattresses with the right combination of tools and techniques.
Step 1
Blot the stain with a clean white cloth to remove excess liquid.
Step 2
Place a few drops of fingernail polish remover containing acetone directly onto the stain with an eye dropper. Blot the area immediately with a clean area of the cloth.
Step 3
Add a few drops of dry cleaning solvent onto the polish stain using the eye dropper. Blot immediately with the white cloth.
Step 4
Repeat step three if the stain remains.
Step 5
Dab the area with a sponge dampened in cold water. Blot dry once more.
Charlotte Johnson
Charlotte Johnson is a musician, teacher and writer with a master's degree in education. She has contributed to a variety of websites, specializing in health, education, the arts, home and garden, animals and parenting.